Memory of a Killer: Patrick Dempsey to Headline New Fox Thriller

Introduction

The upcoming Fox series memory of a killer has attracted attention for its premise and high-profile cast. The programme explores themes of memory, conscience and redemption through the story of a hitman confronting early-onset Alzheimer’s. Its development reflects network interest in European IP adaptations and marks a notable return to broadcast television for several veteran performers.

Main details and development

Production and premiere

Memory of a Killer is an American crime drama developed by Ed Whitmore and Tracey Malone. Fox issued a straight-to-series order on 12 May 2025 and has scheduled the show to premiere on 25 January 2026. The series has been described by the network as a propulsive, edge-of-your-seat thriller and a redemptive story about a man who is losing his memory but gaining a conscience.

Cast and creative team

Patrick Dempsey is announced to headline the series, returning to broadcast television in the lead role. The cast also includes Michael Imperioli, Richard Harmon, Daniel David Stewart, Peter Gadiot, Ian Matthews and Richard Clarkin. Gina Torres has been reported to join the ensemble as well. Across development reports, multiple showrunners have been attached: David Schulner joined as co-showrunner at one stage, and later Aaron Zelman and Glenn Kessler were named to lead the series.

Premise

The central character, Angelo, is a hitman who is struck by early-onset Alzheimer’s. Sources describe the narrative as focusing on Angelo’s struggle as his memory fades while a new conscience emerges, setting up a redemptive arc as he confronts his past. The series is positioned as a thriller with emotional and moral stakes tied to memory loss.

Conclusion

Memory of a Killer arrives at a time when networks are mining international IP and high-concept crime dramas for broadcast slots. With a known lead in Patrick Dempsey, a supporting cast that includes established television actors, and a production order from Fox, the series has potential to draw both conventional drama audiences and viewers interested in character-driven thrillers. As the 25 January 2026 premiere approaches, attention will centre on trailers, critical reception and how the show balances procedural tension with the human story of memory and redemption.